The pangenome structure of human pathogen <i>Mycobacterium kansasii</i>

The non-tuberculous Mycobacterium kansasii , is the causative agent of destructive pulmonary and extrapulmonary infections in immunocompromised persons. Incessant use multiple antibiotics lack effective vaccines did little to combat M. mediated infections. Here, a bioinformatic analysis has been carried out using PanExplorer, analyze pangenome aimed at functional characterization bacterium, understanding it’s pathogenic lifestyle recognize factors shaping evolution variations amongst strains. had large core genome (60.2%), small (11.9%) dispensable 27.9% strain-specific genes. high concentration COGs (Cluster orthologous genes) linked energy production conversion, amino acid transport metabolism, nucleotide coenzyme secondary me-tabolite biosynthesis, metabolism. Interestingly, numerous genes within were associated with pathogenesis virulence. Noteworthy among them type VII secretion, ESX, PP PPE family proteins. Although, genomes revealed overall relatedness conservation, genomic rearrangements caused variability information from this could assist future microbial genomics research on further studies, e.g., concerning distinctive gene clusters, evolution.